Current status for influenza control
Identifieur interne : 001A31 ( Main/Exploration ); précédent : 001A30; suivant : 001A32Current status for influenza control
Auteurs : Kwang-Hee Lee [Corée du Sud] ; Baik L. Seong [Corée du Sud]Source :
- Biotechnology and Bioprocess Engineering [ 1226-8372 ] ; 1999-10-01.
English descriptors
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Abstract
Abstract: Influenza viruses are responsible for respiratory illness with significant morbidity and mortality. To curb the disease, two-pronged attack on the virus, therapeutic and prophylactic, is being actively pursued. The therapeutic use of existing anti-influenza drugs, such as amantadine and rimantadine, is limited by their significant adverse side effect, emergence of resistant viral strains, and lack of activity against influenza B virus. A new class of antiviral agents designed to inhibit influenza neuraminidase are currently under active development for use in the prophylaxis and treatment of influenza A and B virus infections. Two of these compounds, zanamivir (GG167) and GS4104 have reached clinical trials. Limitations in the effectiveness and application of inactivated vaccines have stimulated development of alternative approaches to influenza immunization. One such approach is a live, intranasally administered vaccine, attenuated by cold-adaptation of a master strain with subsequent genetic reassortment with circulating wild-type strains. Recently developed reverse-genetics techniques have made it possible to use RNA viruses as vector. Besides DNA viral vectors, live influenza virus vectors may emerge as a useful alternative for the vaccination against different pathogens.
Url:
DOI: 10.1007/BF02931921
Affiliations:
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Seong</name><affiliation wicri:level="3"><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Biotechnology and Bioproducts Research Center, College of Engineering, Yonsei University, 134 Shinchon-dong, Seodaemun-gu, 120-749, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Corée du Sud</country></affiliation></author></analytic><monogr></monogr><series><title level="j">Biotechnology and Bioprocess Engineering</title><title level="j" type="abbrev">Biotechnol. Bioprocess Eng.</title><idno type="ISSN">1226-8372</idno><idno type="eISSN">1976-3816</idno><imprint><publisher>The Korean Society for Biotechnology and Bioengineering</publisher><pubPlace>Seoul</pubPlace><date type="published" when="1999-10-01">1999-10-01</date><biblScope unit="volume">4</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="157">157</biblScope><biblScope unit="page" to="164">164</biblScope></imprint><idno type="ISSN">1226-8372</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1226-8372</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>antiviral drugs</term><term>genetic manipulation</term><term>influenza virus</term><term>reverse genetics</term><term>vaccine</term><term>viral vector</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Influenza viruses are responsible for respiratory illness with significant morbidity and mortality. To curb the disease, two-pronged attack on the virus, therapeutic and prophylactic, is being actively pursued. The therapeutic use of existing anti-influenza drugs, such as amantadine and rimantadine, is limited by their significant adverse side effect, emergence of resistant viral strains, and lack of activity against influenza B virus. A new class of antiviral agents designed to inhibit influenza neuraminidase are currently under active development for use in the prophylaxis and treatment of influenza A and B virus infections. Two of these compounds, zanamivir (GG167) and GS4104 have reached clinical trials. Limitations in the effectiveness and application of inactivated vaccines have stimulated development of alternative approaches to influenza immunization. One such approach is a live, intranasally administered vaccine, attenuated by cold-adaptation of a master strain with subsequent genetic reassortment with circulating wild-type strains. Recently developed reverse-genetics techniques have made it possible to use RNA viruses as vector. Besides DNA viral vectors, live influenza virus vectors may emerge as a useful alternative for the vaccination against different pathogens.</div></front></TEI><affiliations><list><country><li>Corée du Sud</li></country><region><li>Région capitale de Séoul</li></region><settlement><li>Séoul</li></settlement></list><tree><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Lee, Kwang Hee" sort="Lee, Kwang Hee" uniqKey="Lee K" first="Kwang-Hee" last="Lee">Kwang-Hee Lee</name></region><name sortKey="Seong, Baik L" sort="Seong, Baik L" uniqKey="Seong B" first="Baik L." last="Seong">Baik L. Seong</name><name sortKey="Seong, Baik L" sort="Seong, Baik L" uniqKey="Seong B" first="Baik L." last="Seong">Baik L. Seong</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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